Patient population and study design

Data collection

Randomization

Laboratory analyses

TMAO measurement

Interventional procedures

Interventional product

Fecal microbiome analysis

Statistical analysis

Clinical and demographic patient characteristics

Baseline TMAO levels in patient groups

TMAO level differences as the primary outcome after interventional procedures in different patient groups

Differences in lipid profile and glucose control after interventional procedures in different patient groups

Differences in microbiome analysis after interventional procedures in different patient groups

TMAO synthesis and steps to influence TMAO levels

TMAO levels and probiotic supplementation