Regioselective synthesis of triazolo[3,4-e]purine derivatives and their anti-cancer activity against NCI-60 cell-lines

Khushal Kapadiya; Kishor Kavadia; Jyoti Gohel; Ranjan Khunt

doi:10.3897/folmed.63.e52891

Original Article

Folia Medica 63(2): 213-220
https://doi.org/10.3897/folmed.63.e52891 (30 Apr 2021)

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Green Approach Toward Triazole Forming Reactions for Developing Anticancer Drugs. Current Organic Synthesis 21: 380.

DOI: 10.2174/1570179420666230508125144

N. M. Khadiya, V. A. Modhavadiya (2022)
CuAAC-Ensembled 1,2,3-Triazole-Linked Biphenyl and N-Arylamide Systems as Diverse Antimicrobial Agents. Russian Journal of Organic Chemistry 58: 1058.

DOI: 10.1134/S107042802207017X

Gajanan Sanglikar, Anand Kumar Tengli (2025)
A critical review on purine and pyrimidine heterocyclic derivatives and their designed molecules in Cancer. Results in Chemistry 15: 102210.

DOI: 10.1016/j.rechem.2025.102210

Bhumit L. Gondaliya, Khushal M. Kapadiya (2023)
Efficient Green Chemistry Approach for the Synthesis of 1,2,3-Triazoles Using Click Chemistry through Cycloaddition Reaction: Synthesis and Cytotoxic Study. Polycyclic Aromatic Compounds 43: 686.

DOI: 10.1080/10406638.2021.2019804

Mital Bhatt, Khushal Kapadiya, Jignesh Kamdar, Jatin Upadhyay (2025)
Design, synthesis and biological evaluation of novel C-6 and N-9 modified purine nucleosides as EGFR kinase inhibitor. Results in Chemistry 18: 102715.

DOI: 10.1016/j.rechem.2025.102715

Alpesh Shah, Nishith Teraiya, Jignesh H. Kamdar, Tanzil Juneja, Chetan B. Sangani, Sarfaraz Ahmed, Khushal Kapadiya (2024)
Novel purine derivatives as selective CDK2 inhibitors with potential anticancer activities: Design, synthesis and biological evaluation. Bioorganic Chemistry 153: 107841.

DOI: 10.1016/j.bioorg.2024.107841

Abhishek Chaurasiya, Chandrakant Sahu, Simranpreet K. Wahan, Pooja A. Chawla (2023)
Targeting cancer through recently developed purine clubbed heterocyclic scaffolds: An overview. Journal of Molecular Structure 1280: 134967.

DOI: 10.1016/j.molstruc.2023.134967

Jyoti Kuchhadiya, Jignesh Kamdar, Khushal M. Kapadiya (2025)
Novel pyrazole-clubbed pyrimidine conjugates as anti-cancer agents in MCF-7 cell line: Design, synthesis, DFT and ADME study. Synthetic Communications 55: 1561.

DOI: 10.1080/00397911.2025.2582186

Mahesh Rupapara, Nishith Teraiya, Chetan Sangani, Khushal Kapadiya, Nishant Patel (2025)
Discovery of novel purine analogues against breast cancer selectively targeting CDK2: optimization, synthesis, biological evaluation and docking study. Molecular Diversity : .

DOI: 10.1007/s11030-025-11227-1

Muhammad Aown Hashmi, Aqsa Kanwal, Umme Habibah Siddiqua, Nasir Rasool, Ayesha Malik (2025)
From molecule to medicine: introducing emerging strategies to synthesize potent anticancer purine scaffolds. RSC Advances 15: 21604.

DOI: 10.1039/D5RA02893K

Qianlu Xing, Jiangdong Li, Yanjiao Shen, Lu He, Xiaojuan Ma, Pei Huang, Qiang Huang, Yan Chen (2026)
Development and bio-evaluation of novel indolizine derivatives in FLT3 mutant acute myeloid leukemia cells. Bioorganic & Medicinal Chemistry Letters 130: 130429.

DOI: 10.1016/j.bmcl.2025.130429

Sobhan Rezayati, Maryam Manafi Moghadam, Ali Ramazani (2026)
Nitrogen Heterocycles in Cancer Therapy. : 143.

DOI: 10.1016/B978-0-443-33106-0.00006-1

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