Lysophospholipid signalling in the pathogenesis of NAFLD. ATX: autotaxin; CHOP: C/EBP homologous protein; CL: cardiolipin; JNK: c-jun N-terminal kinase; MCP1: monocyte chemoattractant protein 1; LPA: lysophosphatidic acid; LPC: lysophosphatidylcholine; LCL: lysocardiolipin; LPE: lysophosphatidylethanolamine; LPG: lysophosphatidylglycerol; LPI: lysophosphatidylinositol; LPSer: lysophosphatidylserine; NFkB: nuclear factor kB; PG: phosphatidylglycerol; PPARγ: peroxisome proliferator-activated receptor γ; PUMA: P53 upregulated modulator of apoptosis; ROCK1: Rho associated protein kinase 1; SREBP-1c: sterol regulatory element protein 1c; S1PR1: sphingosine 1-phosphate receptor 1; S1PR3: sphingosine 1-phosphate receptor 3; S1P: sphingosine 1-phosphate; TNF-α: tumor necrosis factor α. This figure was created using Servier Medical Art templates, which are licensed under a Creative Commons Attribution 3.0 Unported License; https://smart.servier.com.