Folia Medica 62(1): 195-199, doi: 10.3897/folmed.62.e47875
Primary Peritoneal Serous Carcinoma Detected by Abnormal Cervical Smear: a Case Report
expand article infoNikolaos Blontzos, Christos Iavazzo, Eirini Giovannopoulou, George Galanopoulos, Victoria Psomiadou, George Vorgias
‡ Metaxa Memorial Cancer Hospital, Athens, Greece
Open Access

Primary peritoneal serous carcinoma (PPSC) is a rare malignancy, the clinical characteristics of which resemble ovarian serous carcinoma. We present a rare case of PPSC detected by an abnormal cervical smear, the first one with an absence of ovarian tissue at the time of the initial diagnosis.

A 59-year-old asymptomatic woman presented with glandular atypia on routine Papanicolaou smear. Endocervical and endometrial curettage showed an adenocarcinoma with focal squamous differentiation and uncertain further classification. The patient had a past surgical history of bilateral salpingoophorectomy due to endometriosis. Abdominal MRI depicted omental multinodularity, great amount of ascites and possible endometrial tumor. The patient underwent total hysterectomy, omentectomy and biopsies of implants on Douglass pouch.  Surgical and histological findings were consistent with primary peritoneal serous carcinoma. 

Abnormal pap smear could rarely be suggestive of extrauterine malignancies, such as peritoneal cancer.

cervical smear, extrauterine malignancies, glandular atypia, primary peritoneal serous carcinoma