Assel Kudaibergenova‡, Nurettin Aydogdu‡, Nihayet Kandemir‡, Muhammed Ali Aydin‡Corresponding author: Nurettin Aydogdu ( naydogdu@hotmail.com ) © Assel Kudaibergenova, Nurettin Aydogdu, Nihayet Kandemir, Muhammed Ali Aydin. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Citation:
Kudaibergenova A, Aydogdu N, Kandemir N, Aydin MA (2020) Investigation of Kisspeptin Role in Experimental Kidney Ischemia/Reperfusion Injury. Folia Medica 62(1): 82-88. https://doi.org/10.3897/folmed.62.e47913 |  |
Introduction: Kisspeptin is biologically active peptide encoded by the KISS1 gene that is structurally found in the kidney tubule, collecting duct and vein smooth muscle cells.
Aim: We aimed to investigate the role of kisspeptin in kidney function and renal pathophysiology in experimental kidney ischemia/reperfusion (I/R) injury.
Materials and methods: Male Spraque-Dawley rats were divided into control and I/R groups (n=8). Both kidney vessels of I/R group rats were clamped and subjected to ischemia for 60 minutes and reperfusion for 48 hours. After the reperfusion period blood samples and kidney tissue were collected under anesthesia.
Results: Levels of urea, creatinine (p<0.01) in serum, Kim-1 in urine (p<0.05) were increased, creatinine clearance, aldosterone and ANG II levels in serum were decreased in the I/R group compared with the Control group (p<0.05). Kidney kisspeptin levels decreased and urine kisspeptin levels increased (p<0.05).
Conclusions: The present study has shown that the levels of kisspeptin change in kidney damage and thus the kisspeptin may play a role in the regulation of renal function and in the pathophysiology of acute kidney injury.