Folia Medica 62(2): 412-417, doi: 10.3897/folmed.62.e49815
Large-cell Neuroendocrine Carcinoma of the Endometrium in Myomatous Uterus
expand article infoSpasimir T. Shopov, Benyamin L. Anavi§, Dobrin K. Krastev|
‡ Medical University of Plovdiv, Plovdiv, Bulgaria§ Thorax Dr Sava Boyadzhiev Hospital of Obstetrics and Gynecology, Plovdiv, Bulgaria| Parvomai Ltd Hospital, Parvomai, Bulgaria
Open Access

Large-cell neuroendocrine carcinoma of the endometrium is an insufficiently researched aggressive tumor with a short survival regard­less of the treatment type.

We present here the 38th consecutive case of literature reported cases of large cell neuroendocrine carcinoma of the endometrium (posi­tive for synaptophysin, CD56, chromogranin A, p53, and Vimentin) found in the myomatous uterus of a 76-year-old woman.

We also describe in the study the morphological algorithm for differentiation of malignant blastomas with small (under 10 %) neuro-endocrinal component.

Accumulated clinical and morphological evidence raises the question whether the large-cell and the small-cell neuroendocrine carcino­mas are just different variations according to their histology and topical occurrence (uterine body/cervix) or they are just independent forms with their respective clinical signs, morphology, treatment, and prognosis.

immunohistochemistry, large-cell neuroendocrine carcinoma of the endometrium, myomatous uterus