Folia Medica 62(4): 736-745, doi: 10.3897/folmed.62.e51120
Follow-up Evaluation of Association between Weight Changes, Metabolic, and Hormonal Outcomes in Children – a Single-center Pilot Study
expand article infoIoana Țaranu§, Sorana D. Bolboacă, Victoria Creț§
‡ Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania§ Clinical Emergency Paediatric Hospital, Cluj-Napoca, Romania
Open Access

Introduction: Fasting blood glucose, insulin level, and lipid profile are the minimal tests according to the Romanian guidelines to evaluate obese children. Cross-sectional studies for pediatric obesity in Romania focused only on epidemiology and management. 

Aim: Our study aimed to evaluate the metabolic and hormonal changes in association with follow-up bodyweight modifications.

Materials and methods: Medical charts of overweight or obese children presenting at the First Paediatric Hospital, Cluj-Napoca from January 2017 to March 2019 were retrospectively evaluated. Anthropometric measures [e.g., body mass index (BMI), and waist circumference] and blood tests such as inflammatory markers (e.g., white blood cell and neutrophil absolute/relative counts, C-reactive protein), metabolic parameters (e.g., liver enzymes, uric acid, fasting blood glucose, triglycerides, high-density lipoprotein-cholesterol), fasting blood insulin, and cortisol levels were evaluated.

Results: Twenty-two overweight or obese children (17 girls, median age of 13 years) monitored on median for 7.5 months were in-cluded in the study. Blood glucose level significantly decreased (p=0.010) and fasting insulin levels increased (p=0.051) at follow-up evaluation, independently of BMI-for-age z-score. Fasting insulin levels were associated with waist circumference (Spearman’s rank cor-relation coefficient) ρ=0.58, p=0.030). BMI-for-age z-score proved to be associated with the C-reactive protein level at baseline (ρ=0.70, p=0.036, n=9) and high-density lipoprotein cholesterol at follow-up (ρ=-0.52, p=0.033, n=17).

Conclusions: Present analysis found changes in fasting insulin levels in relation to the abdominal circumference and high-density lipoprotein cholesterol and C-reactive protein levels in relation to BMI-for-age z-score in obese children. 

follow-up study, pediatric obesity, practice guideline