Branimir Spassov‡, Donka Vassileva‡, Svetoslav Nikolov‡, Penka Ganeva‡, Gueorgui Balatzenko‡, Margarita Guenova‡Corresponding author: Branimir Spassov ( b.spassov@hematology.bg ) © Branimir Spassov, Donka Vassileva, Svetoslav Nikolov, Penka Ganeva, Gueorgui Balatzenko, Margarita Guenova. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Citation:
Spassov B, Vassileva D, Nikolov S, Ganeva P, Balatzenko G, Guenova M (2020) Absolute Monocyte and Platelet Counts May Provide Additional Prognostic Information in Primary Gastric Diffuse Large B-cell Lymphoma Patients Treated with Rituximab and CHOP. Folia Medica 62(4): 785-801. https://doi.org/10.3897/folmed.62.e51402 |  |
Introduction: Primary gastric diffuse large B cell lymphoma (PG-DLBCL) is the most common histological subtype of primary gastric lymphoma. The standard of care of PG-DLBCL patients is the combination rituximab-based immunochemotherapy (R-CHOP). Re-cently, different host-related factors have been shown to have significant prognostic significance in non-Hodgkin lymphoma. However, data regarding their prognostic contribution to PG-DLBCL are limited.
Aim: To assess the prognostic impact of a panel of simple, cost-effective laboratory variables which are easy to apply in routine labora-tory use for R-CHOP-treated PG-DLBCL patients in an attempt to identify those among them that are high-risk category.
Materials and methods: We retrospectively assessed the possible prognostic impact of different laboratory markers in 42 R-CHOP treated PG-DLBCL patients treated between 2004 and 2014 and followed at a single institution.
Results: The estimated 5-year overall (OS) and progression-free survival (PFS) of the whole group were 80.9% and 78%, respectively. The absolute monocyte and platelet counts in univariate analysis predicted PFS and OS when analyzed as continuous and dichotomized variables. On multivariate analysis performed with factors included in the stage-modified International Prognostic Index (m-IPI), the absolute monocyte and platelet counts remained independent predictors of PFS and OS. Therefore, the absolute monocyte and platelet counts were combined to generate a prognostic index that identified patients with an especially poor overall survival.
Conclusions: This prognostic index was independent of the m-IPI and could provide additional prognostic information for better stratification of these patients.