Folia Medica 63(4): 586-590, doi: 10.3897/folmed.63.e56124
Concurrent treatment of HIV, disseminated Mycobacterium avium complex and HCV-infection
expand article infoVera Zimina, Svetlana Degtyareva, Elena Beloborodova, Julia Klimova, Alexey Kravchenko§
‡ RUDN University, Moscow, Russia§ Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare, Moscow, Russia
Open Access
Patients with HIV-infection diagnosed at late stages usually have significant immunosuppression and demand simultaneous antiretroviral therapy and treatment of opportunistic infections. The presence of HCV coinfection makes treatment even more challenging because of possible adverse effects and drug-drug interactions. HCV cure in such clinical situations not only prevents fibrosis progression, but can also enhance virologic and/or immunologic response to antiretrovirals and thus effective treatment of opportunistic infections. Thorough consideration of all existing diseases and drug interactions of the combined therapy makes simultaneous treatment of HIV, chronic hepatitis C, and opportunistic infections not only possible but the best way to improve outcomes in a complex clinical situation.
co-infection, drug interactions, hepatitis C, immunosuppression, non-tuberculous mycobacteria