Folia Medica 63(6): 913-918, doi: 10.3897/folmed.63.e59216
Dosage of Lipid Emulsions as an Antidote to Lipid-Soluble Substances
expand article infoGabriela Kehayova, Snezha Zlateva, Petko Marinov
‡ Department of Pharmacology, Toxicology and Pharmacotherapy, Faculty of Pharmacy, Medical University, Varna, Bulgaria, Varna, Bulgaria
Open Access

Introduction: Lipid emulsions are increasingly used as an antidote to lipophilic drug intoxications. The dose recommended by the American Society of Regional Anesthesia is used primarily for the treatment of local anesthetic systemic toxicity. There is insufficient information about what the dose of lipid emulsions (LE) should be in other intoxications depending on their severity.

Aim: To determine the LE dose in a shock or haemodynamic instability in patients with acute exogenous intoxications treated with LE.

Materials and methods: Forty-nine patients with acute lipophilic drug intoxications were treated with LE in the Clinic of Toxicology at the Naval Hospital in Varna.

Statistical analysis was performed using the statistical functions of Excel 2016 and the Statistica 7.0 software package.

Results: The percentage of patients receiving a low dose of LE of 0.3 ml/kg (93.87%) was significantly higher than the percentage of patients treated with a medium (2.04%) and a high dose (4.08%) of LF. The high dose of LE of 1.5 ml/kg recommended by the American Society of Regional Anesthesia was administered to two patients (4.08%). In severe intoxications with exotoxic shock, the rate of LE administration varies from 20 ml/h to 40 ml/h.

Conclusions: In severe intoxications with cardiotoxic syndrome and haemodynamic instability, LE should be used in the dose as suggested by the American Society of Regional Anesthesia. It is possible to use lower doses of LE in the range of 0.3–0.6 ml/kg in all moderate poisonings administered by continuous intravenous infusion for 12-24-48 hours. No side effects were observed at these doses.

acute drug intoxication, dosage of lipid emulsion, lipid emulsion