Case Report |
Corresponding author: Katina Shtereva ( katinashtereva@gmail.com ) © 2022 Nikola Boyanov, Katina Shtereva, Katerina Madzharova, Vladimir Andonov, Neno Shopov, Petko Dimov.
This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Citation:
Boyanov N, Shtereva K, Madzharova K, Andonov V, Shopov N, Dimov P (2022) Initial experience with peroral endoscopic myotomy in Bulgaria: case series. Folia Medica 64(6): 982-984. https://doi.org/10.3897/folmed.64.e90599
|
Achalasia is a rare motility disorder with unknown etiology that results in failure of relaxation of the lower esophageal sphincter (LES). As there is no etiological treatment, different pharmacological agents and invasive techniques have been used for relieving the symptoms. For the past decade, peroral endoscopic myotomy (POEM) has proven to have excellent results.
We present a retrospective study of five patients that underwent POEM for primary achalasia. We used anterior approach for the submucosal tunneling. The procedure showed immediate results and no severe short- or long-term adverse events. We have been following the patients up for more than 3 years now.
Since its invention more than ten years ago, the POEM procedure and its advantages and disadvantages compared to the pneumatic dilatation and the Heller myotomy have been extensively studied. There is still no universal opinion on which procedure should be the first line treatment.
anterior approach, Heller myotomy, pneumatic dilatation, POEM
Primary achalasia is a motility disorder with yet undiscovered etiology that is thought to be either viral, autoimmune or neurodegenerative.[
This is a retrospective study on the initial five patients we performed POEM on - four males and one female. All of them had symptoms of dysphagia and retrosternal pain, as well as weight reduction. Their symptoms were graded according to the Eckardt scoring system, as it is the most frequently used one when it comes to achalasia.[
The procedure was performed under general anesthesia and the patients were placed in supine position. A forward-viewing endoscope with a transparent distal cap was used. At the beginning, the distance between the dentition and the cardia of every subject was measured. After injecting a high molecule solution of adrenaline, gelofusine and Indigo Carmine, linear incision was positioned on the front wall of the esophagus, approximately at two o’clock, between eight and seventeen centimeters proximal of the gastroesophageal junction (GEJ). Submucosal tunnel was created from there to two centimeters distal of the GEJ, onto the gastric cardia. Once the submucosal tunnel was completed, full-thickness myotomy of the lower esophageal sphincter was performed, followed by one to two centimeters myotomy in the cardia. The tunnel was sealed with Endoclips only after the relaxation of the LES was verified. On the following day, new upper GI series were ordered, this time with peroral ingestion of urografin to confirm once again the success of the procedure and lack of perforation.
None of the subjects had severe adverse events in the early post-procedural period. In all of them subcutaneous emphysema was observed which resorbed by itself in the next couple of days. In one of the cases, classified as type III achalasia, necrosis of the mucosa occurred about 28 days after the POEM.
The subjects were endoscopically controlled at two months and at one year after the procedure. One had mild reflux and another one did not comply with the endoscopic follow-up program but kept in touch and did not report any residual symptoms. Furthermore, their symptoms, if any, were once again graded according to the Eckardt system. The comparison between the preprocedural and postprocedural score showed excellent results in relieving the symptoms.
The POEM procedure was first performed on humans in 2008 by Inoue et al.[
Moreover, when measuring clinical outcomes of POEM and pneumatic dilatation (PD), the second most used endoscopic technique for treatment of achalasia, the patients that underwent POEM showed significantly better short- and long-term outcomes.[
Since fundoplication is not performed along with POEM, as it is with Heller myotomy, the development of gastroesophageal reflux disease was a major concern. Studies show that the frequency of GERD differs according to the method used for its diagnosis – symptom development, pH monitoring and endoscopic findings.[
Per-oral endoscopic myotomy is a safe, minimally-invasive procedure, that shows excellent clinical outcomes and symptoms reduction when used for the treatment of achalasia. It can be used as a therapy of choice, compared to the Heller myotomy and pneumatic dilatation.